The study describes the variations of gout flares and assesses the different methods of gout flare reporting in clinical trials. Among patients with gout, the wide variation of flare patterns presents ...

First in human phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of KU-0059436 (Ku), a small molecule inhibitor of poly ADP-ribose polymerase (PARP) in cancer patients (p), including BRCA1/2 ...